Today is the last day for the long running strip Cathy by Cathy Guisewite.
Yep, the noseless few fingered chick is pregnant with a girl.
The only toon to notice (that I can tell) is Liō. Bloom County's Opus and The Boondocks' Huey Freeman are riding off into an unfinished panel with Cathy - a nod to Calvin and Hobbes as they walked away into an unfinished panel - only with characters from other retired strips. Perhaps Calvin is driving? You can't see the driver of the convertible.
Cathy's pregnancy would certainly have been a gold mine for new material, but apparently Guisewite was suffering from burnout. Personally, I think Cathy jumped the shark a long time ago and was rarely relevant or funny for quite a while. At least Guisewite was still writing and drawing her strip rather than farming it out to others, or going to reruns. Even so, it's still kinda sad to see a cultural touchstone end.